Dynamic analysis of light‐driven DNA strand displacement. (6th February 2019)

• Record Type: Journal Article
• Authors: Kou, Bo; Shen, Wufeng; Zhou, Haonan; Xia, Weikang
• Is Part Of: Micro & nano letters. Volume 14:Number 2(2019)
• Page Start: 116
• Page End: 119
• Publication Date: 2019-02-06
• Subjects: reaction rate constants -- molecular biophysics -- free energy -- DNA; strand displacement reaction rate constants -- light‐driven DNA strand displacement -- photosensitive azobenzene‐tethered DNA material -- DNA nanomachines -- data fitting -- sequence designs -- Gibbs free energy -- azobenzene; Nanotechnology -- Periodicals; Nanostructures -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1049/mnl.2018.5299
• Languages: English
• ISSNs: 1750-0443

Abstract

Abstract : The photosensitive azobenzene‐tethered DNA material provides an ideal force for DNA nanomachines. This work demonstrates the process of light‐driven DNA strand displacement by physical and mathematical models. By data fitting, the strand displacement reaction rate constants under different sequence designs are discussed in detail. The results showed that the Gibbs free energy induced by azobenzene is around 2.52 kJ mol −1, which would hinder the light‐driven strand displacement reaction. Increasing the length of the sticky ends can increase the displacement rate exponentially, but the displacement rate will not increase when it exceeds 12 bases.