Hexamethylene‐1, 3‐bis(cetyldimethylammonium bromide) protected low‐toxicity ZnSe quantum dots as fluorescent probe for proteins. (1st May 2015)

• Record Type: Journal Article
• Authors: Zhong, Yaping; Deng, Chun; He, Yu; Ge, Yili; Song, Gongwu
• Is Part Of: Micro & nano letters. Volume 10:Number 5(2015)
• Page Start: 236
• Page End: 240
• Publication Date: 2015-05-01
• Subjects: proteins -- molecular biophysics -- biochemistry -- surfactants -- radiation quenching -- fluorescence -- optical sensors -- zinc compounds -- II‐VI semiconductors -- wide band gap semiconductors -- semiconductor quantum dots -- nanosensors; detection limit -- correlation coefficient -- fluorescence intensity -- surfactant G16‐6‐16 protected ZnSe QD nanometre material -- fluorescence quenching -- hydrophobic effect -- bovine serum albumin -- proteins -- fluorescent probe -- low‐toxicity ZnSe quantum dots -- hexamethylene‐1, 3‐bis(cetyldimethylammonium bromide); Nanotechnology -- Periodicals; Nanostructures -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1049/mnl.2014.0698
• Languages: English
• ISSNs: 1750-0443

Abstract

Abstract : Hexamethylene‐1, 3‐bis(cetyldimethylammonium bromide) (G16‐6‐16 ) protected low‐toxicity ZnSe quantum dots (QDs) were successfully synthesised and used as fluorescence probe to detect proteins such as bovine serum albumin (BSA). This method is simple, fast, selective and sensitive. Surfactant G16‐6‐16 can interact with proteins through hydrophobic effect, thus leading to the fluorescence quenching of G16‐6‐16 protected ZnSe QDs nanometre material. The fluorescence intensity of G16‐6‐16 protected ZnSe QDs was linearly proportional to BSA over a concentration range from 0 to 80 nM with a correlation coefficient of 0.993. The detection limit was 0.04 nM. This method was successfully applied to determine BSA in urine samples which shows the good application value of this nanometre material.