Antimicrobial and biofilm-disrupting nanostructured TiO2 coating demonstrating photoactivity and dark activity. Issue 7 (17th April 2021)

• Record Type: Journal Article
• Authors: Wasa, Alibe; Land, Johann G; Gorthy, Rukmini; Krumdieck, Susan; Bishop, Catherine; Godsoe, William; Heinemann, Jack A
• Is Part Of: FEMS microbiology letters. Volume 368:Issue 7(2021)
• Publication Date: 2021-04-17
• Subjects: nanostructured anatase rutile carbon -- antimicrobial activity -- antibiofilm activity -- dark-active photocatalyst -- scanning electron microscopy; Microbiology -- Periodicals; 579
• DOI: 10.1093/femsle/fnab039
• Languages: English
• ISSNs: 0378-1097

Abstract

ABSTRACT: Antimicrobial materials are tools used to reduce the transmission of infectious microorganisms. Photo-illuminated titania (TiO2 ) is a known antimicrobial material. Used as a coating on door handles and similar surfaces, it may reduce viability and colonization by pathogens and limit their spread. We tested the survival of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Saccharomyces cerevisiae on a nano-structured TiO2 -based thin film, called 'NsARC', and on stainless steel under a variety of light wavelengths and intensities. There was significantly less survival ( P <0.001) of all the organisms tested on NsARC compared to inert uncoated stainless steel under all conditions. NsARC was active in the dark and possible mechanisms for this are suggested. NsARC inhibited biofilm formation as confirmed by scanning electron microscopy. These results suggest that NsARC can be used as a self-cleaning and self-sterilizing antimicrobial surface coating for the prevention and reduction in the spread of potentially infectious microbes. Abstract : New photoactive antimicrobial material for coating hard surfaces is effective in multiple wavelengths and has minimal effect on antibiotic resistance.