Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms. (18th July 2020)

• Record Type: Journal Article
• Authors: Ghani, Rohma; Mullish, Benjamin H; McDonald, Julie A K; Ghazy, Anan; Williams, Horace R T; Brannigan, Eimear T; Mookerjee, Siddharth; Satta, Giovanni; Gilchrist, Mark; Duncan, Neill; Corbett, Richard; Innes, Andrew J; Pavlů, Jiří; Thursz, Mark R; Davies, Frances; Marchesi, Julian R
• Is Part Of: Clinical infectious diseases. Volume 72:Number 8(2021)
• Page Start: 1444
• Page End: 1447
• Publication Date: 2020-07-18
• Subjects: antimicrobial resistance -- gut microbiome -- fecal microbiota transplant -- multidrug-resistant bacteria -- allogeneic hematopoietic cell transplantation; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa948
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.