Calcium deficiency in hydroxyapatite and its drug delivery applications. (1st April 2018)

• Record Type: Journal Article
• Authors: Koppala, Sivasankar; Swamiappan, Sasikumar; Gangarajula, Yuvaraj; Xu, Lei; Sadasivuni, Kishor Kumar; Ponnamma, Deepalekshmi; Rajagopalan, Vijayaraghavan
• Is Part Of: Micro & nano letters. Volume 13:Number 4(2018)
• Page Start: 562
• Page End: 564
• Publication Date: 2018-04-01
• Subjects: calcium compounds -- bioceramics -- drug delivery systems -- drugs -- nanoparticles -- particle size -- nanofabrication -- nanomedicine -- Fourier transform infrared spectra -- precipitation -- calcination -- X‐ray diffraction -- scanning electron microscopy -- X‐ray chemical analysis -- nanoporous materials -- porosity; drug delivery applications -- calcium deficient hydroxyapatites -- precipitation method -- calcined samples -- Fourier transformation infrared spectroscopy -- powder X‐ray diffraction -- scanning electron microscopy -- energy‐dispersive X‐ray spectroscopy -- phase purity -- particle size -- particle shape -- HAP structure -- ciprofloxacin -- sustained drug release -- phosphate buffer solution -- porous structure -- [Ca10−x(PO4)6(OH)2]; Nanotechnology -- Periodicals; Nanostructures -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1049/mnl.2016.0675
• Languages: English
• ISSNs: 1750-0443

Abstract

Abstract : In this work, calcium deficient hydroxyapatites (HAPs) [Ca10− x (PO4 )6 (OH)2 ] [where x = 0 − 0.3] were synthesised by precipitation method and calcined samples were characterised by Fourier transformation infrared spectroscopy, powder X‐ray diffraction, scanning electron microscopy and energy‐dispersive X‐ray spectroscopy techniques to check phase purity, calcium deficiency, particle size and shape. The results indicate that the structure of the HAP can tolerate a calcium deficiency up to 0.2. The calcium deficient HAP ( x = 0.1) powder was found to be highly porous with a particle size below 200 nm. This powder was used as a drug delivery carrier for the drug, ciprofloxacin and sustained release of the drug in the phosphate buffer solution was investigated.