Design and optimization of self-nanoemulsifying formulations for lipophilic drugs. (6th March 2015)

• Record Type: Journal Article
• Authors: Zhao, Tianjing; Maniglio, Devid; Chen, Jie; Chen, Bin; Motta, Antonella; Migliaresi, Claudio
• Is Part Of: Nanotechnology. Volume 26:Number 12(2015)
• Publication Date: 2015-03-06
• Subjects: drug delivery systems -- SNEDDS -- essential oil -- Ibuprofen -- drug release; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/0957-4484/26/12/125102
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: The purpose of the current study was to develop and optimize novel self-nanoemulsifying drug delivery systems (SNEDDS) with a high proportion of essential oil as carriers for lipophilic drugs. Solubility and droplet size as a function of the composition were investigated, and a ternary phase diagram was constructed in order to identify the self-emulsification regions. The optimized SNEDDS formulation consisted of lemon essential oil (oil), Cremophor RH40 (surfactant) and Transcutol HP (co-surfactant) in the ratio 50:30:20 (v/v). Ibuprofen was chosen as the model drug. The droplet size, ζ -potential and stability of the drug-loaded optimized formulations were determined. The stability of SNEDDS was proved after triple freezing/thawing cycles and storage at 4 °C and 25 °C for 3 months. In vitro drug release studies of optimized SNEDDS revealed a significant increase of the drug release and release rate in comparison to the Ibuprofen suspension (80% versus approximately 40% in 2 h). The results indicated that these SNEDDS formulations could be used to improve the bioavailability of lipophilic drugs.