Coherent regulation in yeast's cell-cycle network. (13th May 2015)

• Record Type: Journal Article
• Authors: Aral, Neşe; Kabakçıoğlu, Alkan
• Is Part Of: Physical biology. Volume 12:Number 3(2015:Jun.)
• Publication Date: 2015-05-13
• Subjects: coherent gene regulation -- Boolean networks -- yeast cell cycle -- Saccharomyces cereviseae; 87.16.Yc -- 87.17.-d -- 82.39.Rt; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biology -- Data processing -- Periodicals; 570.5
• DOI: 10.1088/1478-3975/12/3/036002
• Languages: English
• ISSNs: 1478-3967

Abstract

Abstract: We define a measure of coherent activity for gene regulatory networks, a property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a demand for energy efficiency and may be selected for under evolutionary pressures. We consider two recent models of the cell-cycle regulatory network of the yeast, Saccharomyces cerevisiae as a case study and calculate their degree of coherence. A comparison with random networks of similar size and composition reveals that the yeast's cell-cycle regulation is wired to yield an exceptionally high level of coherent regulatory activity. We also investigate the mean degree of coherence as a function of the network size, connectivity and the fraction of repressory/activatory interactions.