Horizontal connection method for glass microfluidic devices. (22nd April 2020)

• Record Type: Journal Article
• Authors: Yalikun, Yaxiaer; Ota, Nobutoshi; Ma, Doudou; Tanaka, Yo
• Is Part Of: Micro & nano letters. Volume 15:Number 5(2020)
• Page Start: 333
• Page End: 338
• Publication Date: 2020-04-22
• Subjects: cellular biophysics -- bioMEMS -- microfluidics; horizontal connection method -- glass microfluidic devices -- conventional glass microfluidic system -- vertical connection -- reduced sample loss -- single‐cell flow cytometry -- flow velocity -- pressure drop -- high‐speed analysis; Nanotechnology -- Periodicals; Nanostructures -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1049/mnl.2019.0603
• Languages: English
• ISSNs: 1750-0443

Abstract

Abstract : In a conventional glass microfluidic system, the vertical connection is the most frequently used for connections between a microfluidic device and its peripheral equipment. However, it leads to a significant pressure drop at the inlet of a microfluidic device, decreases the flow velocity, and can introduce few samples than expected. To overcome these problems, a horizontal connection method for glass microfluidic devices, which have advantages such as keeping pressure/flow velocity, compatible with small space, reduced sample loss and convenience for modularisation is reported. These advantages are important for high‐speed analysis on precious samples such as single‐cell flow cytometry. In this work, they proposed a horizontal connection method which showed compatibility with high pressure (at least 0.6 MPa) at inlet without leakage, small loss of injected samples (<0.11%), and 22% faster flow velocity along the direction of applied pressure than that of vertical connection.