Cardiomyocyte contractile force changes in response to AGRWE detected by AFM. (1st May 2019)
- Record Type:
- Journal Article
- Title:
- Cardiomyocyte contractile force changes in response to AGRWE detected by AFM. (1st May 2019)
- Main Title:
- Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
- Authors:
- Qu, YingMin
Zhao, Feihu
Wang, Xinyue
Liu, Jinyun
Li, Jingmei
Song, Zhengxun
Wang, Zuobin - Abstract:
- Abstract : The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure.
- Is Part Of:
- Micro & nano letters. Volume 14:Number 5(2019)
- Journal:
- Micro & nano letters
- Issue:
- Volume 14:Number 5(2019)
- Issue Display:
- Volume 14, Issue 5 (2019)
- Year:
- 2019
- Volume:
- 14
- Issue:
- 5
- Issue Sort Value:
- 2019-0014-0005-0000
- Page Start:
- 511
- Page End:
- 514
- Publication Date:
- 2019-05-01
- Subjects:
- atomic force microscopy -- muscle -- patient treatment -- cardiovascular system -- cellular biophysics -- diseases -- biomechanics
AGRWE -- single beating cardiomyocytes -- cardiomyocyte contractile force changes -- cardiac contractile force -- American ginseng root water extract -- atomic force microscopy -- contractile strain -- AFM -- cardiovascular disease -- newborn rat -- heart rate -- ginseng agents -- cardiac functions -- heart failure treatment
Nanotechnology -- Periodicals
Nanostructures -- Periodicals
Microtechnology -- Periodicals
620.5 - Journal URLs:
- http://digital-library.theiet.org/content/journals/mnl ↗
https://ietresearch.onlinelibrary.wiley.com/journal/17500443 ↗
http://www.theiet.org/ ↗ - DOI:
- 10.1049/mnl.2018.5458 ↗
- Languages:
- English
- ISSNs:
- 1750-0443
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5756.775460
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 16623.xml