A Review of Recent Advances in Benchmark Dose Methodology. Issue 10 (2nd May 2019)

• Record Type: Journal Article
• Authors: Jensen, Signe M.; Kluxen, Felix M.; Ritz, Christian
• Is Part Of: Risk analysis. Volume 39:Issue 10(2019)
• Page Start: 2295
• Page End: 2315
• Publication Date: 2019-05-02
• Subjects: BMDL -- hybrid approach -- model averaging -- risk assessment -- simultaneous inference; Technology -- Risk assessment -- Periodicals; 658.403
• DOI: 10.1111/risa.13324
• Languages: English
• ISSNs: 0272-4332

Abstract

Abstract: In this review, recent methodological developments for the benchmark dose (BMD) methodology are summarized. Specifically, we introduce the advances for the main steps in BMD derivation: selecting the procedure for defining a BMD from a predefined benchmark response (BMR), setting a BMR, selecting a dose–response model, and estimating the corresponding BMD lower limit (BMDL). Although the last decade has shown major progress in the development of BMD methodology, there is still room for improvement. Remaining challenges are the implementation of new statistical methods in user‐friendly software and the lack of consensus about how to derive the BMDL.