A dual-response naphthofluorescein-based fluorescent probe for multiple-channel imaging of cysteine/homocysteine in living cells. Issue 23 (6th June 2018)

• Record Type: Journal Article
• Authors: Yue, Xiuxiu; Li, Wenxiu; Chen, Wenqiang; Zhang, Liangliang; Li, Guofang; Sheng, Jiarong
• Is Part Of: Tetrahedron letters. Volume 59:Issue 23(2018)
• Page Start: 2232
• Page End: 2237
• Publication Date: 2018-06-06
• Subjects: Fluorescent probe -- Naphthofluorescein-based -- Cysteine (Cys) -- Homocysteine (Hcy); Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.04.017
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: A dual-response naphthofluorescein-based fluorescent probe that can selectively sense Cys/Hcy in multiple emission channels was reported in this work. Highlights: Two independent moieties were integrated into a naphthofluorescein dye. This probe can detect of Cys/Hcy in a multiple-channel responsive manner. This probe was capable of visualizing Cys/Hcy in three different emission channels. Abstract: A naphthofluorescein-based fluorescent probe with two independent reaction sites (nitro-2, 1, 3-benzoxadiazole and acrylate moiety) was developed. Integrating these two reaction sites into a single molecule not only can guarantee the selective detection of Cys/Hcy in an elegant fashion, but also can enable Cys/Hcy detection in a multiple-channel responsive manner.