One-pot Sonogashira coupling, hydroamination of alkyne and intramolecular CH arylation reactions toward the synthesis of indole-fused benzosultams. Issue 23 (6th June 2018)

• Record Type: Journal Article
• Authors: Debnath, Sudarshan; Mondal, Shovan
• Is Part Of: Tetrahedron letters. Volume 59:Issue 23(2018)
• Page Start: 2260
• Page End: 2263
• Publication Date: 2018-06-06
• Subjects: Benzosultams -- Sonogashira coupling -- Hydroamination -- CH arylation -- Indole; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.04.081
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A methodology for the preparation of medicinally important Benzosultams. Molecules are completely new and applied Sonogashira coupling for synthesis. There are no any literature procedures, similar to present documented molecules. These products are important in natural product synthesis and medicinal chemistry development. Abstract: A one-pot Sonogashira coupling, hydroamination of alkyne and CH arylation reactions for the synthesis of indole-fused benzosultams are described. This method allows access to a variety of indole-fused seven membered benzosultams in good to excellent yields. The free indolyl nitrogen containing indole-fused benzosultams are also prepared by this method. The structures of the synthesized compounds are confirmed by single crystal XRD studies.