Biological removal of pharmaceuticals by Navicula sp. and biotransformation of bezafibrate. (February 2020)

• Record Type: Journal Article
• Authors: Ding, Tengda; Wang, Suhang; Yang, Bo; Li, Juying
• Is Part Of: Chemosphere. Volume 240(2020)
• Publication Date: 2020-02
• Subjects: Pharmaceuticals -- Removal -- Algae -- Degradation pathways -- Bezafibrate; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.124949
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Pharmaceutically active compounds are of great concern due to their detection frequency in the environment and the unexpected risks. In this study, the simultaneous removal of mixed pharmaceuticals by microalgae was explored using a typical freshwater diatom Navicula sp. Results showed that Navicula sp. could efficiently remove atenolol, carbamazepine, ibuprofen and naproxen with the efficiencies of >90% after 21 d of exposure. As compared to the removal efficiencies of each pharmaceutical in the individual pharmaceutical treatments, the degradation of sulfamethoxazole, bezafibrate, and naproxen was improved in the mixed treatment, whereas the removal efficiencies of carbamazepine and atenolol decreased. Additionally, the presence of hydrophobic pharmaceuticals (i.e., ibuprofen and naproxen) accelerated the degradation of carbamazepine and sulfamethoxazole and inhibited the removal of atenolol in the mixture with the combination of six pharmaceuticals, while the addition of other pharmaceuticals show no significant effect on the removal of ibuprofen and naproxen. The bioaccumulation of pharmaceuticals in Navicula sp. increased as their log KOW values decreased. Four bezafibrate metabolites were identified and the degradation pathways of bezafibrate in diatom were proposed. It is the first report on the metabolism of BEZ in diatom, and further studies on the environmental risk of the metabolites should be investigated. Graphical abstract: Image 1 Highlights: Nearly complete removal of ATE and IBU was observed in the presence of Navicula sp. Removal of CAB inhibited but IBU and NPX enhanced in the mixture. IBU and NPX promoted the elimination of BEZ, CAB and SUL. Negative correlation between log KOW values and bioaccumulation in algae observed. Degradation pathways of bezafibrate are proposed based on 4 identified metabolites.