The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach. Issue 6 (December 2017)

• Record Type: Journal Article
• Authors: Miranda, Andreia Machado; Carioca, Antonio Augusto Ferreira; Steluti, Josiane; da Silva, Ismael Dale Cotrim Guerreiro; Fisberg, Regina Mara; Marchioni, Dirce Maria
• Is Part Of: Clinical nutrition. Volume 36:Issue 6(2017:Dec.)
• Page Start: 1635
• Page End: 1641
• Publication Date: 2017-12
• Subjects: Coffee -- Polyphenol intake -- Metabolomics -- Lysophosphatidylcholines; FFQ Food Frequency Questionnaire -- LDL low-density lipoprotein -- LysoPC lysophosphatidylcholines -- LysoPC a C16:1 palmitoleoyl-glycero-3-phosphocholine -- LysoPC a C18:1 oleoyl-lysophosphatidylcholine -- LysoPC a C18:2 linoleoyl-lysophosphatidylcholine -- LysoPC a C20:4 arachidonoyl-lysophosphatidylcholine -- Ox-LDL oxidized low-density lipoprotein -- 24HR 24-hour dietary recalls; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2016.10.012
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aim: Lysophosphatidylcholines (lysoPC) are known to be a pathological component of oxidized-LDL, and several studies demonstrate its pro-inflammatory properties in vitro . Nevertheless, bioactive compounds found in coffee, such as phenolic acids might inhibit LDL oxidation. The relationship between coffee consumption and lysoPC has not been described previously in humans. The aim of the present study was to assess the association between coffee intake and plasma lysoPC levels in adults. Methods: Data was from the "Health Survey of Sao Paulo (ISA-Capital)", a cross-sectional population-based survey in Sao Paulo, among 169 individuals aged 20 years or older. This population was categorized into three groups: non-coffee consumers (0 mL/day-G1), low coffee consumers (≤100 mL/day-G2), and high coffee consumers (>100 mL/day-G3). Usual coffee intake was estimated by two 24HR and one FFQ, using Multiple Source Method. Quantification of the metabolites was performed by mass spectrometry (FIA-MS/MS and HPLC-MS/MS) and 14 lysoPC species were identified. The association between coffee intake and lysoPC was analyzed by multiple linear regression adjusted for age, sex, household per capita income, smoking, physical activity, body mass index, total energy intake, use of drugs, vegetables and fruit consumption and caffeine intake. Results: LysoPC levels were significantly lower in G3 than in G1, for the lysoPC a C16:1 (β = −0.56; p = 0.014), lysoPC a C18:1 (β = −2.57; p = 0.018), and lysoPC a C20:4 (β = −1.14; p = 0.037). In opposition, the ratios of C16:0/C16:1 and C18:0/18:1 was higher in G3 (β = 5.04; p = 0.025 and β = 0.28; p = 0.003, respectively). Conclusion: LysoPC profile differed according to coffee intake, showing a possible beneficial health effect of this beverage on inflammatory and oxidative processes.