Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants. (February 2020)

• Record Type: Journal Article
• Authors: Dualde, Pablo; Pardo, Olga; Corpas-Burgos, Francisca; Kuligowski, Julia; Gormaz, María; Vento, Máximo; Pastor, Agustín; Yusà, Vicent
• Is Part Of: Chemosphere. Volume 240(2020)
• Publication Date: 2020-02
• Subjects: Parabens -- Human milk -- Infants -- Human biomonitoring -- Mothers -- Estimated daily intake; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.124829
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: In this study, we assessed the presence of four parabens in human milk of 120 mothers from Valencia (Spain) which took part in a human biomonitoring project (BETTERMILK). The detection frequency ranges of parabens were 41–60% and 61–89% for unconjugated- and total (unconjugated + conjugated)-parabens, respectively. The concentrations ranged from <LoQ to 31 ng/mL and from <LoQ to 49 ng/mL for unconjugated- and total-parabens, respectively. The frequency of use of some cosmetic products and human milk protein levels were the main predictors of parabens in milk. The study evidences the presence of both conjugated and unconjugated paraben forms in human milk. The newborns estimated daily intake of parabens through human milk was several orders of magnitude lower than the 0–10 mg/kg bw-day acceptable daily intake for the sum of methyl and ethyl paraben established by EFSA. To our knowledge, this is currently the largest biomonitoring study of parabens in human milk. Highlights: Paraben levels were determined in human milk samples from 120 Spanish mothers. Detection of parabens ranged from 61 to 89% with GMs from 0.10 to 0.36 ng/mL. Both conjugated and unconjugated parabens were present in human milk. Paraben levels were correlated with the frequency of use of cosmetics. Breastfed infants intake of parabens was far below the ADI.