The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats. (April 2021)

• Record Type: Journal Article
• Authors: Song, Yahui; Yu, Jia; Song, Jiale; Wang, Shanglong; Cao, Tingfeng; Liu, Zimin; Gao, Xiang; Wei, Yuxi
• Is Part Of: Journal of functional foods. Volume 79(2021)
• Publication Date: 2021-04
• Subjects: Ruditapes philippinarum -- Bacillus natto -- Peptides -- Antihypertension -- Rats; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104411
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Oral administration of RBPs reduced blood pressures in SHRs. RBPs improved the injuries of kidney, blood vessel and heart in SHRs. RBPs improved hypertension by inhibiting RAS signaling pathway excessive activation. RBPs improved hypertension by maintaining ET-1 / NO secretion balance. RBPs improved intestinal flora disorder in SHRs. Abstract: In our previous study, the clams ( Ruditapes philippinarum ) were inoculated with Bacillus natto and fermented to produce peptides (RBPs) with high ACE inhibitory effect in vitro . In this study, we continued to explore the anti-hypertensive effect and potential mechanisms of RBPs in vivo . The results showed that RBPs significantly reduced both systolic and diastolic blood pressure and alleviated the damage of kidney, thoracic aorta and heart of spontaneously hypertensive rats after 8 weeks of treatment. Meanwhile, RBPs could also inhibit the expression of RAS signaling pathway, maintained the secretion balance of NO/ET-1 in vascular endothelial cells and inhibited the cardiac TGF-β/Smad pathway. Most notably, RBPs could also improve the gut microbiota by decreasing the ratio of Firmicutes and Bacteroidetes and increasing the relative abundance of certain genera, like Ruminococcaceae_UCG-014 . The data suggested that RBPs could be used as functional food ingredient for the improvement of hypertension.