Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis. Issue 49 (18th October 2019)

• Record Type: Journal Article
• Authors: Cui, Chunyan; Fan, Chuanchuan; Wu, Yuanhao; Xiao, Meng; Wu, Tengling; Zhang, Dongfei; Chen, Xinyu; Liu, Bo; Xu, Ziyang; Qu, Bo; Liu, Wenguang
• Is Part Of: Advanced materials. Volume 31:Issue 49(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-18
• Subjects: adhesive -- coacervate -- hemostasis -- hyperbranched polymer -- underwater adhesion; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201905761
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Despite recent advance in bioinspired adhesives, achieving strong adhesion and sealing hemostasis in aqueous and blood environments is challenging. A hyperbranched polymer (HBP) with a hydrophobic backbone and hydrophilic adhesive catechol side branches is designed and synthesized based on Michael addition reaction of multi‐vinyl monomers with dopamine. It is demonstrated that upon contacting water, the hydrophobic chains self‐aggregate to form coacervates quickly, displacing water molecules on the adherent surface to trigger increased exposure of catechol groups and thus rapidly strong adhesion to diverse materials from low surface energy to high energy in various environments, such as deionized water, sea water, PBS, and a wide range of pH solutions (pH = 3 to 11) without use of any oxidant. Also, this HBP adhesive (HBPA) exhibits a robust adhesion to fractured bone, precluding the problem of mismatched surface energy and mechanical properties. The HBPA's adhesion is repeatable in a wet condition. Intriguingly, the HBPA is capable of gluing dissimilar materials with distinct properties. Importantly, introducing long alkylamine into this modular hyperbranched architecture contributes to formation of an injectable hemostatic sealant that can rapidly stop visceral bleeding, especially hemorrhage from deep wound. Abstract : A hyperbranched polymer adhesive fabricated using a ternary Michael addition reaction of hydrophobic multi‐vinyl monomers with dopamine demonstrates strong underwater adhesion to diverse materials without any oxidant. This is due to water‐triggered fast coacervation and increased outward exposure of catechols. Introducing long‐chain alkylamine contributes to the formation of an injectable hemostatic sealant that can rapidly stop visceral bleeding, especially hemorrhage from deep wound.