A single‐center clinical trial to evaluate the efficacy of a tripeptide/hexapeptide antiaging regimen. (4th March 2018)

• Record Type: Journal Article
• Authors: Widgerow, Alan D; Jiang, Lily I; Calame, Antoanella
• Is Part Of: Journal of cosmetic dermatology. Volume 18:Number 1(2019:Feb.)
• Page Start: 176
• Page End: 182
• Publication Date: 2018-03-04
• Subjects: antiaging formulation -- collagenesis -- elastogenesis -- extracellular matrix recycling -- peptides; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.12507
• Languages: English
• ISSNs: 1473-2130

Abstract

Summary: Introduction: An antiaging regimen that aids in clearing the matrix of waste products and stimulating neocollagenesis and neoelastogenesis was tested among a group of subjects over the course of 12 weeks to assess its efficacy in women with mild to moderate wrinkles and skin sagging on the face. Materials and methods: The efficacy of the product regimen was tested in 22 subjects using investigator clinical grading measurements, raking light imaging, 3D imaging, biopsies, and self‐assessment questionnaires at baseline and weeks 4, 8, and 12. Results: Clinical grading indicated that use of the antiaging regimen for 12 weeks produced a statistically significant improvement in scores for all evaluated parameters; the raking light image analysis demonstrated a statistically significant improvement in values for length, width, and area of wrinkles when compared with baseline values as did 3D imaging. Biopsy results in the 5 patients tested showed improvement in solar elastosis, collagen stimulation, and improvement in cornified layers in all 5 patients. Elastin stimulation was evident in 3 of 5 patients. Results from the self‐assessment questionnaire analysis indicated favorable responses in a statistically significant proportion of subjects after 12 weeks of use for all inquiries. Conclusion: Use of this facial antiaging regimen was effective in improving visual facial photoaging conditions and well‐perceived when used by women with mild to moderate wrinkles and skin sagging on the face under the conditions of this study.