A DNA–Azobenzene Nanopump Fueled by Upconversion Luminescence for Controllable Intracellular Drug Release. (24th October 2019)

• Record Type: Journal Article
• Authors: Zhang, Yue; Zhang, Yue; Song, Guobin; He, Yuling; Zhang, Xiaobo; Liu, Ying; Ju, Huangxian
• Is Part Of: Angewandte Chemie. Volume 131:Number 50(2019)
• Page Start: 18375
• Page End: 18379
• Publication Date: 2019-10-24
• Subjects: Azobenzol -- Aufkonvertierende Nanopartikel -- DNA-Nanotechnologie -- Tumortherapeutika -- Wirkstoff-Transport; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201909870
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Stimulus‐responsive drug release possesses considerable significance in cancer therapy. This work reports an upconversion‐luminescence‐fueled DNA–azobenzene nanopump for rapid and efficient drug release. The nanopump is constructed by assembling the azobenzene‐functionalized DNA strands on upconversion nanoparticles (UCNPs). Doxorubicin (DOX) is loaded in the nanopump by intercalation in the DNA helix. Under NIR light, the UCNPs emit both UV and visible photons to fuel the continuous photoisomerization of azo, which acts as an impeller pump to trigger cyclic DNA hybridization and dehybridization for controllable DOX release. In a relatively short period, this system demonstrates 86.7 % DOX release. By assembling HIV‐1 TAT peptide and hyaluronic acid on the system, targeting of the cancer‐cell nucleus is achieved for perinuclear aggregation of DOX and enhanced anticancer therapy. This highly effective drug delivery nanopump could contribute to chemotherapy development. Abstract : Eine DNA‐Nanopumpe auf Basis Azobenzol‐funktionalisierter DNA‐Stränge ermöglicht die effiziente und steuerbare Wirkstoff‐Freisetzung durch Photoisomerisierung von Azobenzol, angetrieben durch die simultanen UV‐ und Vis‐Emissionen aufkonvertierender Nanopartikel. Dies induziert die Freisetzung eines Tumortherapeutikums zur Verbesserung der Krebstherapie.