Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults. (14th April 2021)

• Record Type: Journal Article
• Authors: Lindbergh, Cutter A.; Walker, Nicole; La Joie, Renaud; Weiner-Light, Sophia; Staffaroni, Adam M.; Casaletto, Kaitlin B.; Elahi, Fanny; Walters, Samantha M.; You, Michelle; Cotter, Devyn; Asken, Breton; Apple, Alexandra C.; Tsoy, Elena; Neuhaus, John; Fonseca, Corrina; Wolf, Amy; Cobigo, Yann; Rosen, Howie; Kramer, Joel H.
• Other Names: collab.
• Is Part Of: Journal of the International Neuropsychological Society. Volume 27:Number 4(2021)
• Page Start: 382
• Page End: 388
• Publication Date: 2021-04-14
• Subjects: Alzheimer's disease, -- Cognitive aging, -- Early diagnosis, -- Episodic memory, -- Learning, -- Temporal lobe; Neuropsychology -- Periodicals; 616.8
• DOI: 10.1017/S1355617720001009
• Languages: English
• ISSNs: 1355-6177

Abstract

Abstract: Objective: We evaluated whether memory recall following an extended (1 week) delay predicts cognitive and brain structural trajectories in older adults: Method: : Clinically normal older adults (52–92 years old) were followed longitudinally for up to 8 years after completing a memory paradigm at baseline [Story Recall Test (SRT)] that assessed delayed recall at 30 min and 1 week. Subsets of the cohort underwent neuroimaging ( N = 134, mean age = 75) and neuropsychological testing ( N = 178–207, mean ages = 74–76) at annual study visits occurring approximately 15–18 months apart. Mixed-effects regression models evaluated if baseline SRT performance predicted longitudinal changes in gray matter volumes and cognitive composite scores, controlling for demographics. Results: : Worse SRT 1-week recall was associated with more precipitous rates of longitudinal decline in medial temporal lobe volumes ( p = .037), episodic memory ( p = .003), and executive functioning ( p = .011), but not occipital lobe or total gray matter volumes (demonstrating neuroanatomical specificity; p > .58). By contrast, SRT 30-min recall was only associated with longitudinal decline in executive functioning ( p = .044). Conclusions: : Memory paradigms that capture longer-term recall may be particularly sensitive to age-related medial temporal lobe changes and neurodegenerative disease trajectories. ( JINS, 2020, xx, xx-xx)