A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug–Gene Combinations. Issue 26 (13th June 2019)

• Record Type: Journal Article
• Authors: Liu, Bei; Hu, Feng; Zhang, Jingfang; Wang, Congli; Li, Lele
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 26(2019)
• Page Start: 8804
• Page End: 8808
• Publication Date: 2019-06-13
• Subjects: combination therapy -- drug delivery -- gene delivery -- metal–organic coordination -- nanobiotechnology; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201903417
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Inspired by natural biomineralization processes, a simple and universal strategy is introduced to construct a biomimetic nanoplatform for systemic codelivery of a nucleic acid therapeutic (G3139) and a chemotherapeutic drug doxorubicin (DOX). This codelivery system was synthesized through one‐pot supramolecular self‐assembly of G3139, DOX, and Fe II ions through multiple coordination interactions, followed by an adapted surface mineralization with metal–organic frameworks. The resulting core–shell nanoparticles have uniform size, well‐defined nanosphere structure, robust colloidal stability, ultrahigh drug loading efficiency and capacity, and precisely adjustable ratios of two therapeutic agents. The system can efficiently accumulate in the tumor, allowing for sensitive MRI detection and synergistical inhibition of tumor growth without apparent systemic toxicity. Abstract : Inspired by natural biomineralization, a biomimetic nanoplatform was developed for delivery of drug–gene combinations. The nanoparticles possess uniform size, ultra‐high drug loading efficiency and capacities, and precisely adjustable ratios of two therapeutic agents, thus allowing synergistic inhibition of tumor growth through a combination of gene therapy and chemotherapy.