Mechanical circulatory support for cardiac amyloidosis. Issue 10 (29th July 2019)

• Record Type: Journal Article
• Authors: Kittleson, Michelle M.; Cole, Robert M.; Patel, Jignesh; Ramzy, Danny; Passano, Elizabeth; Chang, David H.; Geft, Dael R.; Czer, Lawrence; Vescio, Robert; Chung, Joshua; Kobashigawa, Jon A.; Arabia, Francisco; Esmailian, Fardad; Moriguchi, Jaime D.
• Is Part Of: Clinical transplantation. Volume 33:Issue 10(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-29
• Subjects: cardiac amyloidosis -- mechanical circulatory support -- total artificial heart; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.13663
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: Cardiac amyloidosis, typically from abnormal deposition of AL or ATTR amyloid protein, can result in heart failure requiring transplantation (HTx). The role of mechanical circulatory support (MCS) is not well‐established. The purpose of this study was to present our experience with MCS in patients with cardiac amyloidosis. Methods: Consecutive patients with cardiac amyloidosis who received MCS at Cedars‐Sinai Medical Center between 2010 and 2018 were reviewed. Clinical characteristics and outcomes were compared to a control group of MCS patients without amyloid matched 2:1 for age and INTERMACS Profile. Results: 11 amyloid patients underwent durable MCS, two with paracorporeal biventricular assist devices and 9 with total artificial hearts. No patients received isolated left ventricular assist device support. By 1 year, 9 (82%) of patients in the MCS‐Amyloid group had been transplanted and 2 (18%) had died. In the MCS‐No Amyloid group, by 1 year, 8 (36%) of patients had been transplanted, 10 (46%) had died, and 4 (18%) were still living with MCS. Conclusions: Over a 9‐year period, patients with amyloid cardiomyopathy who required MCS at our institution all received durable biventricular MCS. For carefully selected patients, this approach is feasible with acceptable outcomes as bridge to transplantation.