Cover Feature: High‐Throughput Measurement of Small‐Molecule Enantiopurity by Using Flow Cytometry (ChemBioChem 17/2018). (16th August 2018)

• Record Type: Journal Article
• Authors: Tan, Zhesen; Heemstra, Jennifer M.
• Is Part Of: Chembiochem. Volume 19:Number 17(2018)
• Page Start: 1794
• Page End: 1794
• Publication Date: 2018-08-16
• Subjects: aptamers -- biocatalysis -- biosensors -- enantiopurity -- flow cytometry; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201800454
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture shows how enantiomeric DNA biosensors can be used for high‐throughput measurement of small‐molecule enantiopurity. The d ‐ and l ‐DNA biosensors each bind selectively to one enantiomer of the target molecule and produce orthogonal fluorescence signals. These signals can be distinguished and quantified by flow cytometry to calculate the enantiopurity of the target small molecule. This method is expected to significantly accelerate the discovery of new asymmetric biocatalysts for the synthesis of pharmaceuticals and other high‐value chemicals. More information can be found in the communication by J. M. Heemstra and Z. Tan on page 1853 in Issue 17, 2018 (DOI: 10.1002/cbic.201800341 ).