Ghrelin regulation of glucose metabolism. (3rd April 2019)

• Record Type: Journal Article
• Authors: Gray, Sarah M.; Page, Laura C.; Tong, Jenny
• Other Names: Abizaid Alfonso guestEditor.; Andrews Zane guestEditor.; Dickson Suzanne guestEditor.; Zigman Jeffrey guestEditor.
• Is Part Of: Journal of neuroendocrinology. Volume 31:Number 7(2019:Jul.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-03
• Subjects: ghrelin -- glucose tolerance -- insulin -- insulin secretion; Neuroendocrinology -- Periodicals; 616.4
• DOI: 10.1111/jne.12705
• Languages: English
• ISSNs: 0953-8194

Abstract

Abstract : Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are implicated in the regulation of glucose metabolism via direct actions in the pancreatic islet, as well as peripheral insulin‐sensitive tissues and the brain. Although many studies have explored the role of ghrelin in glucose tolerance and insulin secretion, a complete mechanistic understanding remains to be clarified. This review highlights the local expression and function of ghrelin and GHSR1a in pancreatic islets and how this axis may modulate insulin secretion from pancreatic β‐cells. Additionally, we discuss the effect of ghrelin on in vivo glucose metabolism in rodents and humans, as well as the metabolic circumstances under which the action of ghrelin may predominate.