Engineering spatiotemporal organization and dynamics in synthetic cells. (21st November 2020)

• Record Type: Journal Article
• Authors: Groaz, Alessandro; Moghimianavval, Hossein; Tavella, Franco; Giessen, Tobias W.; Vecchiarelli, Anthony G.; Yang, Qiong; Liu, Allen P.
• Is Part Of: Wiley interdisciplinary reviews. Volume 13:Number 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-21
• Subjects: artificial cells -- in vitro reconstitution -- protein compartment -- synthetic cell; Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; Biotechnology -- Periodicals; Ultrastructure (Biology) -- Periodicals; 610.28
• DOI: 10.1002/wnan.1685
• Languages: English
• ISSNs: 1939-5116

Abstract

Abstract: Constructing synthetic cells has recently become an appealing area of research. Decades of research in biochemistry and cell biology have amassed detailed part lists of components involved in various cellular processes. Nevertheless, recreating any cellular process in vitro in cell‐sized compartments remains ambitious and challenging. Two broad features or principles are key to the development of synthetic cells—compartmentalization and self‐organization/spatiotemporal dynamics. In this review article, we discuss the current state of the art and research trends in the engineering of synthetic cell membranes, development of internal compartmentalization, reconstitution of self‐organizing dynamics, and integration of activities across scales of space and time. We also identify some research areas that could play a major role in advancing the impact and utility of engineered synthetic cells. This article is categorized under: Biology‐Inspired Nanomaterials > Lipid‐Based Structures Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures Abstract : Self‐organizing systems and dynamics in space and time in synthetic cells.