Campylobacter jejuni capsule types in a Peruvian birth cohort and associations with diarrhoeal disease severity. (2019)

• Record Type: Journal Article
• Authors: Neitenbach, Britney; Poly, Frédéric; Kuroiwa, Janelle; Burga, Rosa; Olortegui, Maribel Paredes; Guerry, Patricia; Kosek, Margaret; Porter, Chad K.
• Is Part Of: Epidemiology and infection. Volume 147(2019)
• Publication Date: 2019
• Subjects: Campylobacter jejuni, -- capsule types, -- multiplex PCR, -- paediatric enteric disease, -- vaccine development; Communicable diseases -- Periodicals; Epidemiology -- Periodicals; 614.4
• DOI: 10.1017/S0950268818002960
• Languages: English
• ISSNs: 0950-2688

Abstract

Abstract: Campylobacter jejuni is a leading cause of bacterial diarrhoea worldwide. The objective of this study was to examine the association between C. jejuni capsule types and clinical signs and symptoms of diarrhoeal disease in a well-defined birth cohort in Peru. Children were enrolled in the study at birth and followed until 2 years of age as part of the Malnutrition and Enteric Infections birth cohort. Associations between capsule type and clinical outcomes were assessed using the Pearson's χ 2 and the Kruskal–Wallis test statistics. A total of 318 C. jejuni samples (30% from symptomatic cases) were included in this analysis. There were 22 different C. jejuni capsule types identified with five accounting for 49.1% of all isolates. The most common capsule types among the total number of isolates were HS4 complex ( n = 52, 14.8%), HS5/31 complex ( n = 42, 11.9%), HS15 ( n = 29, 8.2%), HS2 ( n = 26, 7.4%) and HS10 ( n = 24, 6.8%). These five capsule types accounted for the majority of C. jejuni infections; however, there was no significant difference in prevalence between symptomatic and asymptomatic infection (all p > 0.05). The majority of isolates ( n = 291, 82.7%) were predicted to express a heptose-containing capsule. The predicted presence of methyl phosphoramidate, heptose or deoxyheptose on the capsule was common.