Estimated Glomerular Filtration Rate as a Predictor of Restenosis After Carotid Stenting Using First-Generation Stents. (September 2021)

• Record Type: Journal Article
• Authors: Ösken, Altuğ; Akdeniz, Evliya; Keskin, Muhammed; Öz, Ahmet; Ipek, Göktürk; Zehir, Regayip; Barutça, Hakan; Çam, Neşe; Şahin, Sinan
• Is Part Of: Angiology. Volume 72:Number 8(2021)
• Page Start: 762
• Page End: 769
• Publication Date: 2021-09
• Subjects: carotid artery stenting -- carotid intervention -- glomerular filtration rate -- in-stent restenosis -- restenosis; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/00033197211014684
• Languages: English
• ISSNs: 0003-3197

Abstract

This study evaluated the impact of the baseline estimated glomerular filtration rate (eGFR) on clinical and angiographic outcomes and long-term in-stent restenosis (ISR) rates in patients undergoing elective carotid artery stenting (CAS) procedures. Consecutive patients who underwent CAS were retrospectively enrolled (n = 456). At the end of 3 years of follow-up, patients who had died or were lost follow-up were excluded from the study and a final analysis was performed using data from the remaining 405 patients. The study population (n = 405) was divided into 3 tertiles based on the tertile values of the eGFR level (T1, T2, and T3); then, clinical and procedural characteristics and 3-year ISR rates were compared between the groups. An ISR of 50% was detected in 49 (12%) surviving patients. The 3-year ISR was higher among patients with the lowest eGFR values (T1) by 3.7 times (95% CI: 2.01-11.38) than that among patients with the highest eGFR values (T3). These significant relationships persisted following adjustment for confounders. A lower baseline eGFR level was significantly associated with an increased ISR rate. Decreased renal function may be a predictor of ISR after CAS using first-generation stents.