Impact and outcomes of postoperative anaemia in colorectal cancer patients: a systematic review. (9th January 2021)

• Record Type: Journal Article
• Authors: Moncur, Aileen; Chowdhary, Manish; Chu, Yajing; Francis, Nader K
• Is Part Of: Colorectal disease. Volume 23:Number 4(2021)
• Page Start: 776
• Page End: 786
• Publication Date: 2021-01-09
• Subjects: colorectal cancer -- postoperative anaemia -- prevalence -- outcome; Colon (Anatomy) -- Diseases -- Periodicals; Rectum -- Diseases -- Periodicals; 616.34
• DOI: 10.1111/codi.15461
• Languages: English
• ISSNs: 1462-8910

Abstract

Abstract: Aim: Preoperative anaemia is common in colorectal cancer patients. Little attention has been given to the prevalence and consequences of postoperative anaemia. The aim of this study was to systematically review the published literature and determine the knowledge of the prevalence and impact of postoperative anaemia in colorectal cancer patients. Methods: The databases Cumulative Index of Nursing and Allied Health Literature (CINAHL) and Medline, via EBSCOhost, were systematically searched to identify suitable articles published between 2004 and 2020. After an initial search, articles were screened and all eligible articles reporting on the prevalence of postoperative anaemia and clinical and long‐term outcome data in colorectal cancer patients undergoing surgery were included. The Risk of Bias 2.0 tool for the assessment of randomized controlled trials and the Risk of Bias 1.0 tool for non‐randomized studies were used for the assessment of bias in the studies selected in our review. Results: Six studies, one randomized control trial and five cohort studies, were included with a total population size of 1714. The prevalence of anaemia at discharge of 76.6% was reported as the primary end‐point in only one study. The rate of red blood cell transfusion and length of hospital stay were found to be significantly increased in anaemic patients, while postoperative infection rate results were variable. Quality of life scores and overall survival at 5 years were significantly affected among anaemic patients as reported in two papers. Conclusion: The available limited evidence on postoperative anaemia indicates its high prevalence with negative impact on clinical and long‐term outcomes. Further research is required to standardize the measurement and address the true impact of correcting postoperative anaemia on functional and oncological outcomes.