Contemporary management of breast cancer in Nigeria: Insights from an institutional database. Issue 12 (9th February 2021)

• Record Type: Journal Article
• Authors: Olasehinde, Olalekan; Alatise, Olusegun; Omisore, Adeleye; Wuraola, Funmilola; Odujoko, Oluwole; Romanoff, Anya; Akinkuolie, Akinbolaji; Arowolo, Olukayode; Adisa, Adewale; Knapp, Gregory; Famurewa, Olusola; Omisile, Idowu; Onabanjo, Emmanuella; Constable, Jeremy; Omoniyi‐Esan, Ganiyat; Adesunkanmi, Abdul‐Rasheed; Lawal, Oladejo; Kingham, Thomas P.
• Is Part Of: International journal of cancer. Volume 148:Issue 12(2021)
• Page Start: 2906
• Page End: 2914
• Publication Date: 2021-02-09
• Subjects: breast -- cancer -- database -- low‐ and middle‐income country -- survival; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.33484
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract: High‐quality data are needed to guide interventions aimed at improving breast cancer outcomes in sub‐Saharan Africa. We present data from an institutional breast cancer database to create a framework for cancer policy and development in Nigeria. An institutional database was queried for consecutive patients diagnosed with breast cancer between January 2010 and December 2018. Sociodemographic, diagnostic, histopathologic, treatment and outcome variables were analyzed. Of 607 patients, there were 597 females with a mean age of 49.8 ± 12.2 years. Most patients presented with a palpable mass (97%) and advanced disease (80.2% ≥ Stage III). Immunohistochemistry was performed on 21.6% (131/607) of specimens. Forty percent were estrogen receptor positive, 32.8% were positive for HER‐2 and 43.5% were triple negative. Surgery was performed on 49.9% (303/607) of patients, while 72% received chemotherapy and 7.9% had radiotherapy. At a median follow‐up period of 20.5 months, the overall survival was 43.6% (95% CI −37.7 to 49.5). Among patients with resectable disease, 18.8% (57/303) experienced a recurrence. Survival was significantly better for early‐stage disease (I and II) compared to late‐stage disease (III or IV) (78.6% vs 33.3%, P < .001). Receipt of adjuvant radiotherapy after systemic chemotherapy was associated with improved survival in patients with locally advanced disease (68.5%, CI −46.3 to 86 vs 51%, CI 38.6 to 61.9, P < .001). This large cohort highlights the dual burden of advanced disease and inadequate access to comprehensive breast cancer care in Nigeria. There is a significant potential for improving outcomes by promoting early diagnosis and facilitating access to multimodality treatment. Abstract : What's new? Despite being a leading cause of cancer deaths in Nigeria, data on breast cancer, particularly long‐term outcomes of the disease, remain limited. In the present study, sociodemographic and disease‐related variables were analyzed among breast cancer patients, using data from a prospective institutional database on current breast cancer management in Nigeria. Analyses show that most patients had advanced disease at diagnosis and that stage at presentation significantly impacted survival. The findings highlight the importance of early diagnosis and access to care and provide a reference for current and future breast cancer interventions in Nigeria.