MBene as a Theranostic Nanoplatform for Photocontrolled Intratumoral Retention and Drug Release. Issue 16 (18th March 2021)

• Record Type: Journal Article
• Authors: Chen, Danyang; Jin, Zhaokui; Zhao, Bin; Wang, Yingshuai; He, Qianjun
• Is Part Of: Advanced materials. Volume 33:Issue 16(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-18
• Subjects: controlled release -- drug delivery -- enhanced intratumoral retention -- gas therapy -- nanomedicine -- theranostics -- 2D materials; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202008089
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Tumor‐targeted drug delivery by nanomaterials is important to improve tumor therapy efficacy and reduce toxic side effects, but its efficiency is quite limited. In this work, a new type of MBene, zirconium boride nanosheet (ZBN), as a versatile nanoplatform to realize near‐infrared (NIR)‐controlled intratumoral retention and drug release is developed. ZBN exhibits high NIR‐photothermal conversion efficiency (76.8%), surface modification with hyaluronic acid (HA) by polyol−borate esterfication endows ZBN‐HA with good dispersion, and the photopyrolysis of borate ester causes HA detachment and ZBN aggregation, enabling NIR‐controlled intratumoral retention to achieve high intratumoral accumulation. By virtue of surface borate esterfication, polyol chemotherapeutic drug (doxorubicin, DOX), and NO prodrug (β‐galactosyl‐diazeniumdiolate, Gal‐NO) can be efficiently and stably conjugated on the surface of ZBN‐HA (1.21 g DOX or 0.57 g Gal‐NO per gram ZBN) without visible drug leakage, and the photopyrolysis of borate ester enables NIR‐controlled drug release with high responsiveness and controllability. Combined chemothermal/gasothermal therapies based on ZBN‐HA/DOX and ZBN‐HA/NO nanomedicines eradicate primary tumors and interdict tumor metastasis by changing the tumor microenvironment and killing cancer cells in primary tumors. The developed NIR‐photothermal MBene is confirmed as a versatile nanoplatform capable of high‐efficacy tumor‐targeted drug delivery and controlled drug release. Abstract : 2D zirconium boride nanosheets (ZBNs) are developed as a versatile drug delivery nanoplatform to realize near infrared (NIR)‐controlled intratumoral retention and drug release by the photopyrolysis of borate ester on the surface. Combined chemothermal/gasothermal therapies based on ZBN eradicate primary tumors and interdict tumor metastasis by changing the tumor microenvironment.