A novel minimal motif for left-handed G-quadruplex formation. Issue 20 (8th February 2021)
- Record Type:
- Journal Article
- Title:
- A novel minimal motif for left-handed G-quadruplex formation. Issue 20 (8th February 2021)
- Main Title:
- A novel minimal motif for left-handed G-quadruplex formation
- Authors:
- Das, Poulomi
Winnerdy, Fernaldo Richtia
Maity, Arijit
Mechulam, Yves
Phan, Anh Tuân - Abstract:
- Abstract : A novel minimal motif ( Motif2 ) for left-handed G-quadruplex (LHG4) formation has been discovered, highlighting the role of split guanines and single thymine loops in promoting LHG4 structures. Abstract : A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
- Is Part Of:
- Chemical communications. Volume 57:Issue 20(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 20(2021)
- Issue Display:
- Volume 57, Issue 20 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 20
- Issue Sort Value:
- 2021-0057-0020-0000
- Page Start:
- 2527
- Page End:
- 2530
- Publication Date:
- 2021-02-08
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc08146a ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 16566.xml