Fabrication of multiple molecular logic gates made of fluorescent DNA-templated Au nanoclusters. (17th February 2021)

• Record Type: Journal Article
• Authors: Wang, Hai-Bo; Mao, An-Li; Tao, Bei-Bei; Zhang, Hong-Ding; Liu, Yan-Ming
• Is Part Of: New journal of chemistry. Volume 45:Number 9(2021)
• Page Start: 4195
• Page End: 4201
• Publication Date: 2021-02-17
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj06192a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A universal platform of label-free multiple molecular logic gates have been constructed by taking the advantage of DNA-AuNCs. Abstract : Molecular logic computation has drawn extensive attention in the fields of bioanalysis, intelligent diagnostics of diseases and other nanotechnology areas. DNA-templated Au nanoclusters (DNA-AuNCs) possess some excellent features, including high luminescence, good photo-stability and easy preparation. Herein, taking these advantages of DNA-AuNCs, we have designed and constructed a universal platform of label-free and enzyme-free multiple molecular logic gates, including NOR, XNOR, IMPLY, OR, AND, and INHIBIT. The experimental results have demonstrated the feasibility of these logic gates operations using Hg 2+, Cu 2+, biothiols, melamine and pyrophosphate (PPi) as inputs. Thus, the universal platform can be utilized for the determination of biothiols, melamine and pyrophosphate (PPi) via logic outputs. The strategy exhibited low cost, easy operation and versatile design, and can offer a promising platform for the development of functional logic systems.