Advancements in nanotherapeutics for Alzheimer's disease: current perspectives. (15th July 2019)
- Record Type:
- Journal Article
- Title:
- Advancements in nanotherapeutics for Alzheimer's disease: current perspectives. (15th July 2019)
- Main Title:
- Advancements in nanotherapeutics for Alzheimer's disease: current perspectives
- Authors:
- Harilal, Seetha
Jose, Jobin
Parambi, Della Grace Thomas
Kumar, Rajesh
Mathew, Githa Elizabeth
Uddin, Md Sahab
Kim, Hoon
Mathew, Bijo - Abstract:
- Abstract: Objectives: Considerable progress has been made in the treatment of Alzheimer's disease (AD), but all available strategies focus on alleviating symptoms rather than curing, which means that AD is viewed as an unresolvable neurodegenerative disease. Nanotechnological applications offer an alternative platform for the treatment of neurodegenerative diseases. This review aims to summarize the recent nanomedicine and nanotechnology developments for the treatment of AD. Key findings: A plethora of nanocarriers and nanoparticle prodrugs have been reported to have negligible cytotoxicity in animal models, and these developments have revealed new opportunities for development of new classes of potent drug formulations for AD. Different nanotechnology-based approaches such as polymers, emulsions, lipo-carriers, solid lipid carriers, carbon nanotubes and metal-based carriers have been developed over the past decade, and they have been focusing on both neuroprotective and neurogenerative techniques to treat AD. Studies also reveal that nanotechnological approaches can aid in early diagnosis of AD and enhance therapeutic efficacy and bioavailability. Summary: Notably, the drugs used conventionally to target the central nervous system have limitations that include an inability to cross the 'blood–brain barrier' or the 'blood–cerebrospinal fluid barrier' effectively and high drug efflux due to the activity of P-glycoprotein, but these limitations can be successfully overcomeAbstract: Objectives: Considerable progress has been made in the treatment of Alzheimer's disease (AD), but all available strategies focus on alleviating symptoms rather than curing, which means that AD is viewed as an unresolvable neurodegenerative disease. Nanotechnological applications offer an alternative platform for the treatment of neurodegenerative diseases. This review aims to summarize the recent nanomedicine and nanotechnology developments for the treatment of AD. Key findings: A plethora of nanocarriers and nanoparticle prodrugs have been reported to have negligible cytotoxicity in animal models, and these developments have revealed new opportunities for development of new classes of potent drug formulations for AD. Different nanotechnology-based approaches such as polymers, emulsions, lipo-carriers, solid lipid carriers, carbon nanotubes and metal-based carriers have been developed over the past decade, and they have been focusing on both neuroprotective and neurogenerative techniques to treat AD. Studies also reveal that nanotechnological approaches can aid in early diagnosis of AD and enhance therapeutic efficacy and bioavailability. Summary: Notably, the drugs used conventionally to target the central nervous system have limitations that include an inability to cross the 'blood–brain barrier' or the 'blood–cerebrospinal fluid barrier' effectively and high drug efflux due to the activity of P-glycoprotein, but these limitations can be successfully overcome when nanocarriers are used for targeted drug delivery in AD. … (more)
- Is Part Of:
- Journal of pharmacy and pharmacology. Volume 71:Number 9(2019)
- Journal:
- Journal of pharmacy and pharmacology
- Issue:
- Volume 71:Number 9(2019)
- Issue Display:
- Volume 71, Issue 9 (2019)
- Year:
- 2019
- Volume:
- 71
- Issue:
- 9
- Issue Sort Value:
- 2019-0071-0009-0000
- Page Start:
- 1370
- Page End:
- 1383
- Publication Date:
- 2019-07-15
- Subjects:
- Alzheimer's disease -- blood–brain barrier -- cerebrospinal fluid -- nanomedicine -- neurodegenerative diseases
Pharmacy -- Periodicals
Pharmacology -- Periodicals
615.1 - Journal URLs:
- https://academic.oup.com/jpp ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2042-7158 ↗
http://onlinelibrary.wiley.com/ ↗
http://www.ingentaconnect.com/content/rpsgb/jpp ↗ - DOI:
- 10.1111/jphp.13132 ↗
- Languages:
- English
- ISSNs:
- 0022-3573
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5034.000000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 16567.xml