Nanomedicine: a new paradigm to overcome drug incompatibilities. (21st May 2020)

• Record Type: Journal Article
• Authors: Abdelkader, Ayat; Fathi, Heba A; Hamad, Mostafa A; Elsabahy, Mahmoud
• Is Part Of: Journal of pharmacy and pharmacology. Volume 72:Number 10(2020)
• Page Start: 1289
• Page End: 1305
• Publication Date: 2020-05-21
• Subjects: intravenous -- nanocarriers -- physicochemical drug incompatibilities; Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.13292
• Languages: English
• ISSNs: 0022-3573

Abstract

Abstract: Objectives: Drug incompatibilities may compromise the safety and effectiveness of combined drugs and result in mild-to-serious clinical complications, such as catheter obstruction, loss of drug efficacy, formation of toxic derivatives and embolism. Various preventive strategies have been implemented to overcome drug incompatibilities with limited success. This review presents an innovative approach to prevent drug incompatibilities via isolating the incompatible drugs into nanostructures. Key findings: Several examples of incompatible drugs may be loaded separately into nanostructures of various types. Physicochemical characteristics and biocompatibility of the nanomaterials that are being utilized to prevent physicochemical incompatibilities should be carefully considered. Conclusions: There is a new era of exploiting nanomaterials in overcoming various types of physicochemical incompatibilities, with additional benefits of further improvements in pharmacokinetic profiles and pharmacological actions of the administered drugs.