Nano-engineering of biomedical prednisolone liposomes: evaluation of the cytotoxic effect on human colon carcinoma cell lines. (30th January 2018)

• Record Type: Journal Article
• Authors: Lorente, Cristina; Arias, José L; Cabeza, Laura; Ortiz, Raúl; Prados, José C; Melguizo, Consolación; Delgado, Ángel V; Clares-Naveros, Beatriz
• Is Part Of: Journal of pharmacy and pharmacology. Volume 70:Number 4(2018)
• Page Start: 488
• Page End: 497
• Publication Date: 2018-01-30
• Subjects: antiproliferative effect -- cancer chemotherapy -- haemocompatibility -- liposomes -- prednisolone; Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12882
• Languages: English
• ISSNs: 0022-3573

Abstract

Abstract: Objectives: Liposomes have attracted the attention of researchers due to their potential to act as drug delivery systems for cancer treatment. The present investigation aimed to develop liposomes loaded with prednisolone base and the evaluation of the antiproliferative effect on human colon carcinoma cell lines. Methods: Liposomes were elaborated by following a reproducible thin film hydration technique. The physicochemical characterization of liposomes included photon correlation spectroscopy, microscopy analysis, Fourier transform infrared spectroscopy, rheological behaviour and electrophoresis. On the basis of these data and drug loading values, the best formulation was selected. Stability and drug release properties were also tested. Key findings: Resulting liposomes exhibited optimal physicochemical and stability properties, an excellent haemocompatibility and direct antiproliferative effect on human colon carcinoma T-84 cell lines. Conclusions: This study shows direct antitumour effect of prednisolone liposomal formulation, which opens the door for liposomal glucocorticoids as novel antitumour agents.