Nanostructured hybrids for the improvement of folic acid biopharmaceutical properties. (13th October 2016)

• Record Type: Journal Article
• Authors: Pagano, Cinzia; Tiralti, Maria Cristina; Perioli, Luana
• Is Part Of: Journal of pharmacy and pharmacology. Volume 68:Number 11(2016:Nov.)
• Page Start: 1384
• Page End: 1395
• Publication Date: 2016-10-13
• Subjects: dissolution enhancement -- folic acid -- hydrotalcite -- nanostructured hybrids -- tablets; Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12634
• Languages: English
• ISSNs: 0022-3573

Abstract

Abstract: Objectives: Folic acid (FA) is an important source for the prevention of many diseases. However, its use is limited because the very low solubility (<10 mg/l particularly in the gastric environment) responsible for the incomplete adsorption of the administered dose. This study proposes a technological strategy to overcome this problem enhancing FA dissolution rate by means of a formulation able to make completely bioavailable the whole administered dose. Methods: Folic acid was intercalated in the layered double hydroxides (LDHs) MgAl-LDH and ZnAl-LDH. The obtained inorganic–organic nanostructured hybrids MgAl-LDH-FA and ZnAl-LDH-FA were deeply characterized and used to prepare immediate release tablets presenting very simple compositions. The hybrids, both as simple powders and as tablets, were submitted to in-vitro release studies mimic the gastric environment conducted both in sink and non-sink conditions. Key findings: Folic acid release from hybrids, as single powders or as tablets, resulted enhanced in both experiments in comparison with crystalline FA. Conclusions: Obtained results showed that FA-LDH nanostructured hybrids are a promising strategy able to enhance the active ingredient dissolution at low pH values representing a promising approach suitable to realize innovative and effective nutraceutical products.