Assessment of possible immunotoxicity of the antipsychotic drug clozapine. (10th December 2013)

• Record Type: Journal Article
• Authors: Abdelrahman, Yaseen; Fararjeh, Mohammad; Abdel-Razeq, Wesam; Mohammad, Mohammad K; Bustanji, Yasser
• Is Part Of: Journal of pharmacy and pharmacology. Volume 66:Number 3(2014:Mar.)
• Page Start: 378
• Page End: 386
• Publication Date: 2013-12-10
• Subjects: Balb/c mice -- clozapine -- DTH -- hemagglutination titre -- immunotoxicity; Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12150
• Languages: English
• ISSNs: 0022-3573

Abstract

Abstract: Objectives: The immunomodulatory effects of clozapine (CLZ), antipsychotic drug, were investigated in vivo using female Balb/c mice. The main aim of this study was to evaluate the immunomodulatory effects of CLZ, antipsychotic drug, following daily intraperitoneal injection to female Balb/c mice over a period of 21 days. Methods: Mice were divided into five groups, eight animals per group. Group I, served as a control group, received only the vehicle. Groups II–V received a daily intraperitoneal dose of CLZ (1, 5, 10 and 20 mg/kg, respectively) over a period of 21 days. Key findings: CLZ has shown a significant decrease in the animal body weight, and it showed a significant decrease in the percentage of circulating neutrophils and lymphocytes while circulating monocytes were increased. The immunotoxicity has been also assessed by evaluating spleen cellularity, humoral immune response to a foreign antigen using sheep red blood cells and delayed-type hypersensitivity reaction. The results showed a marked suppression in these responses in CLZ-treated mice compared with the control group. Detectable changes have also been noticed in the histology of the footpad tissue and spleen. Conclusions: Results showed significant immunomuodulatory effects of CLZ when used in Balb/c mice.