Preparation, characteristic and pharmacological study on inclusion complex of sulfobutylether-β-cyclodextrin with glaucocalyxin A. (12th February 2014)

• Record Type: Journal Article
• Authors: Ren, Lili; Jing, Jianghui; Chen, Guoguang; Miao, Yanfei; Wei, Ping
• Is Part Of: Journal of pharmacy and pharmacology. Volume 66:Number 7(2014:Jul.)
• Page Start: 927
• Page End: 934
• Publication Date: 2014-02-12
• Subjects: characterization -- cyclodextrin -- glaucocalyxin A -- inclusion complex; Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12219
• Languages: English
• ISSNs: 0022-3573

Abstract

Abstract: Objectives: The objective of this study was to improve the water solubility and solubility of glaucocalyxin A (GLA) by producing its inclusion complex with sulfobutylether-β-cyclodextrin (SBE-β-CD). Methods: The formation of its 1 : 1 complex with SBE-β-CD in solution was confirmed by phase-solution and spectral-shift studies. The interaction of GLA and SBE-β-CD was examined by differential scanning calorimetry, powder X-ray diffraction, Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy and ultraviolet-visible spectroscopy to determine the formation of the GLA–SBE-β-CD inclusion complex. Key findings: The solubilities of GLA and its complexes were 2.38 × 10 2 and 1.82 × 10 4 μg/ml, respectively, and the values of the inclusion complexes were significantly improved by 76-fold compared with the solubility of free GLA. Moreover, a higher area under the curve0–∞ after inclusion technique was observed in the pharmacokinetics study. Conclusions: The aforementioned results indicate that GLA–SBE-β-CD could be useful with a better solubility and sustained function in drug delivery.