Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients. Issue 2 (4th November 2020)

• Record Type: Journal Article
• Authors: Onda, Yoshiyuki; Kanda, Junya; Sakamoto, Soichiro; Okada, Mutsumi; Anzai, Naoyuki; Umadome, Hiroshi; Tashima, Masaro; Haga, Hironori; Watanabe, Chihiro; Hanaoka, Nozomu; Fujimoto, Tsuguto; Takaori‐Kondo, Akifumi
• Is Part Of: Transplant infectious disease. Volume 23:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-04
• Subjects: acute liver failure -- adenovirus hepatitis -- allo‐HSCT; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13496
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Human adenovirus (HAdV) is an important cause of the common cold and epidemic keratoconjunctivitis in immunocompetent individuals. In immunocompromised patients, HAdV can sometimes cause severe infection such as cystitis, gastroenteritis, pneumonia, encephalitis, hepatitis, or disseminated disease, resulting in significant morbidity and also mortality. In particular, severe cases have been reported in patients after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Indeed HAdV has been recognized as a pathogen that requires careful monitoring in allo‐HSCT patients. While HAdV hepatitis leading to severe acute liver failure is rare, such liver failure progresses rapidly and is often fatal. Unfortunately, HAdV hepatitis has few characteristic symptoms and physical findings, which makes it difficult to promptly confirm and start treatment. We report here four cases of HAdV hepatitis after allo‐HSCT and their autopsy findings.