Anti‐apoptotic and pro‐survival effects of longan flower extracts on rat hearts with fructose‐induced metabolic syndrome. Issue 6 (21st January 2021)

• Record Type: Journal Article
• Authors: Cheng, Shiu‐Min; Kumar, V. Bharath; Wu, Liang‐Yi; Chang, Hsiao‐Chuan; Kuo, Chia‐Hua; Wei, Li‐Shan; Lin, Yueh‐Min; Padma, V. Vijaya; Lee, Shin‐Da; Huang, Chih‐Yang
• Is Part Of: Environmental toxicology. Volume 36:Issue 6(2021)
• Page Start: 1021
• Page End: 1030
• Publication Date: 2021-01-21
• Subjects: apoptosis -- Fas receptor -- fructose -- heart -- longan flower -- metabolic syndrome; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.23101
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: The aim of this study was to investigate the effects of longan flower (LF) water extract on cardiac apoptotic and survival pathways in rat models of fructose‐induced metabolic syndrome. The study findings revealed that the levels of glucose, insulin, triglyceride, and cholesterol and TUNEL‐positive apoptotic cells were significantly increased in the HF group compared with the control group; whereas, the levels were decreased in the HFLF group. The expressions of Fas, FADD, and activated caspases 8 and 3, as well as the expressions of Bax, Bak, Bax/Bcl‐2, Bak/Bcl‐xL, cytosolic cytochrome c, and activated caspases 9 and 3 were increased in the HF group were significantly reversed in HFLF administrated group. Furthermore, LF extract increased IGF‐1R, p‐PI3K, p‐Akt, Bcl‐2, and Bcl‐xL expression compared to HF group. Taken together, the present findings help identify LF as a potential cardioprotective agent that can be effectively used in treating fructose‐induced metabolic syndrome.