A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature. Issue 6 (5th April 2021)

• Record Type: Journal Article
• Authors: Keenan, Camille; Ramirez, Nicole; Elijovich, Lucas; Klimo, Paul; Bag, Asim K.; Acharya, Sahaja; Upadhyaya, Santhosh A.
• Is Part Of: Pediatric blood & cancer. Volume 68:Issue 6(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-04-05
• Subjects: arteriovenous fistula -- choriocarcinoma syndrome -- metastatic intracranial germ cell tumor -- serum beta‐hCG; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.29000
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra‐CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.