Effects of probiotics on bowel function restoration following ileostomy closure in rectal cancer patients: a randomized controlled trial. (19th December 2020)

• Record Type: Journal Article
• Authors: Yoon, Byung Jun; Oh, Heung‐Kwon; Lee, Jeehye; Cho, Jung Rae; Kim, Myung Jo; Kim, Duck‐Woo; Kang, Sung‐Bum
• Is Part Of: Colorectal disease. Volume 23:Number 4(2021)
• Page Start: 901
• Page End: 910
• Publication Date: 2020-12-19
• Subjects: microbiota -- dysbiosis -- probiotics -- low anterior resection syndrome -- ileostomy repair; Colon (Anatomy) -- Diseases -- Periodicals; Rectum -- Diseases -- Periodicals; 616.34
• DOI: 10.1111/codi.15463
• Languages: English
• ISSNs: 1462-8910

Abstract

Abstract: Aim: The aim was to determine the efficacy of probiotics in restoring bowel function following ileostomy reversal in patients with rectal cancer. Method: This was a pilot, randomized, double‐blind, placebo‐controlled trial. The probiotic used in this study, Lactobacillus plantarum CJLP243, was derived from kimchi. Patients were randomly allocated to a probiotic or placebo group and medication was taken once daily from preoperative day 1 to day 21. Primary outcomes were the Memorial Sloan Kettering Cancer Centre Bowel Function Index (MSKCC BFI) instrument and the low anterior resection syndrome score. The secondary outcomes were the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 and CR29 questionnaire responses. Results: Forty patients were enrolled, and 36 patients (probiotics, n = 17; placebo, n = 19) completed the primary outcomes. Total scores for the MSKCC questionnaire (56.2 ± 12.0 vs. 55.0 ± 10.7, P = 0.356) and low anterior resection syndrome scores (33.3 ± 7.6 vs. 36.0 ± 5.3, P = 0.257) were not significantly different between the probiotic and placebo groups, respectively. In the MSKCC BFI, the postoperative dietary scale score at week 1 was significantly higher in the probiotic group (13.1 ± 3.8 vs. 9.0 ± 3.0, P < 0.001). There were no other significant differences between the two groups for any other questionnaire scores. Conclusion: There were no significant effects supporting the use of a probiotic for improved bowel function in patients following ileostomy reversal. Nevertheless, the administration of probiotics showed trends toward improvements in some subscale bowel function measures, suggesting further studies may be warranted.