Boryl Radical‐Mediated C−H Activation of Inactivated Alkanes for the Synthesis of Internal Alkynes. Issue 9 (4th November 2020)

• Record Type: Journal Article
• Authors: Han, Jia‐Bin; San, Htet Htet; Guo, Ao; Wang, Long; Tang, Xiang‐Ying
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 9(2021)
• Page Start: 2366
• Page End: 2370
• Publication Date: 2020-11-04
• Subjects: pyridine-boryl radical -- alkynylation -- C−H functionalization -- inactivated alkanes; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000772
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An intriguing pyridine‐boryl radical‐mediated C−H alkynylation reaction of inactivated alkanes was described. The reaction features mild operation condition and wide substrate scope, and affords the corresponding products in moderate to good yields. Notably, The presence of 4‐cyanopyride N‐oxide was key to the success of the reaction. Cyclohexane are more easily to be functionalized in this reaction than toluene, which could be rationally explained by polarity‐match principle. Abstract :