Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells. Issue 6 (10th March 2021)

• Record Type: Journal Article
• Authors: Shu, Chih‐Wen; Weng, Jing‐Ru; Chang, Hsueh‐Wei; Liu, Pei‐Feng; Chen, Jih‐Jung; Peng, Chien‐Chi; Huang, Jia‐Wen; Lin, Wei‐Yu; Yen, Ching‐Yu
• Is Part Of: Environmental toxicology. Volume 36:Issue 6(2021)
• Page Start: 1173
• Page End: 1180
• Publication Date: 2021-03-10
• Subjects: ATG4B -- autophagy -- oral cancer -- plant extract; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.23116
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: Elevated autophagy is highly associated with cancer development and progression. Fruit extracts of several plants inhibit activity of autophagy‐related protease ATG4B and autophagy activity in colorectal cancer cells. However, the effects of these plant extracts in oral cancer cells remain unclear. In this study, we found that the extracted Tribulus terrestris fruit (TT‐(fr)) and Xanthium strumarium fruit had inhibitory effects on autophagy inhibition in both SAS and TW2.6 oral cancer cells. Moreover, the fruit extracts had differential effects on cell proliferation of oral cancer cells. In addition, the fruit extracts hampered cell migration and invasion of oral cancer cells, particularly in TT‐(fr) extracts. Our results indicated that TT‐(fr) extracts consistently inhibited autophagic flux, cell growth and metastatic characteristics of oral cancer cells, suggesting TT‐(fr) might contain function ingredient to suppress oral cancer cells.