The relation between the ghrelin receptor and FOXP3 in bladder cancer. (19th May 2021)

• Record Type: Journal Article
• Authors: Karimi, Monireh; Heshmati, Masoud; Fattahi, Soheila; Bagheri, Nader; Alibeigi, Faramarz Mohammad; Taheri, Fatemeh; Anjomshoa, Maryam; Jami, Mohammad-Saeid; Ghatreh Samani, Mahdi
• Is Part Of: Biotechnic & histochemistry. Volume 96:Number 4(2021)
• Page Start: 287
• Page End: 295
• Publication Date: 2021-05-19
• Subjects: Bladder cancer -- FOXP3 -- GHS-R1a -- human -- Treg cells; Histochemistry -- Periodicals; Stains and staining (Microscopy) -- Periodicals; Biotechnology -- Periodicals; 572
• DOI: 10.1080/10520295.2020.1799074
• Languages: English
• ISSNs: 1052-0295

Abstract

ABSTRACT: Immune responses play an important role in the fate of bladder cancer tumors. Treg cells are immunosuppressive and down-regulate the proliferation of effector T cells, which favor tumor survival. Ghrelin is a hormone that stimulates release of growth hormone and anti-inflammatory response to cancer cells. Ghrelin also is a gastrointestinal hormone that regulates immune responses via the growth hormone secretagogue receptor (GHS-R1a). The relation among ghrelin, its receptor, and Treg cells that surround bladder tumors is not clear. We found that Foxp3 + T and GHS-R1a cells are increased significantly in bladder tumor tissues. Therefore, we suggest that ghrelin may increase the number of Treg cells in the tumor and suppress activity of the immune system against bladder cancer.