CD8+GITR+ T cells may negatively regulate T cell overactivation in aplastic anemia. (19th May 2021)

• Record Type: Journal Article
• Authors: Huang, Guixuan; Zhang, Yuping; Wei, Xiaolei; Yu, Zhi; Lai, Jing; Shen, Qi; Chen, Xiaohui; Tan, Guangxiao; Chen, Cunte; Luo, Weifeng; Li, Yumiao; Zhou, Ming; Li, Yangqiu; Li, Bo
• Is Part Of: Immunological investigations. Volume 50:Number 4(2021)
• Page Start: 406
• Page End: 415
• Publication Date: 2021-05-19
• Subjects: Aplastic anemia -- T cell activation -- glucocorticoid-induced tumor necrosis factor receptor; Immunology -- Periodicals; Immunochemistry -- Periodicals; Cellular immunity -- Periodicals; Communicable diseases -- Periodicals; 616.079
• DOI: 10.1080/08820139.2020.1770785
• Languages: English
• ISSNs: 0882-0139

Abstract

ABSTRACT: Aplastic anemia (AA) is a T cell immune-mediated autoimmune disease. Overactivated CD8 + T cells play a leading role in the pathogenesis of AA, which may be due to disbalance in costimulatory and coinhibitory signals in T cells. In this study, we firstly investigated the expression of OX40, 4–1BB, GITR, ICOS, CTLA-4, LAG-3, and TIM-3 on CD8 + T cells from untreated patients with AA and healthy individuals (HIs) by flow cytometry. Moreover, we further analyzed the phenotype and functional characteristics of CD8 + GITR + T cells to more fully assess the T cell activation dysfunction in AA. We for the first time demonstrated significantly decreased percentage of CD8 + GITR + T cells in AA, and CD8 + GITR + CTLA-4 + T cells were significantly higher in patients with AA compared with HIs. Conversely, the percentage of CD8 + GITR + granzyme B + and CD8 + GITR + perforin + T cells in AA patients was significantly reduced. Our preliminary data illustrate that the CD8 + GITR + T cell population might negatively regulate overactive T cell activation in AA.