Maternal peripheral blood CD34+ cells for prediction of fetal kidney malformations: results from a case-control analysis. (19th May 2021)

• Record Type: Journal Article
• Authors: Giordano, Domenico; Cernaro, Valeria; Scilipoti, Mariagrazia; Cosentino, Sonia; Inferrera, Ramona; Fresta, Jlenia; Andreucci, Michele; Conti, Giovanni; Buemi, Michele; D'Anna, Rosario; Coppolino, Giuseppe
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 34:Number 10(2021)
• Page Start: 1679
• Page End: 1682
• Publication Date: 2021-05-19
• Subjects: CD34+ -- fetal kidney malformations -- first trimester -- hematopoietic stem cells -- maternal; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2019.1645828
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Purpose: To evaluate the relation between CD34 + cells count in maternal blood and potential development of fetal congenital renal abnormalities. Materials and methods: We enrolled 16 women that gave birth to newborns carrying congenital renal malformations over a 3-year period and 48 women with uncomplicated pregnancies (controls) in a 1:3 ratio (three controls per case). Results: CD34 + cells in the maternal peripheral blood were significantly lower in the group of women who gave birth to newborns carrying congenital renal malformations compared to the controls ( p < .0001). Conclusions: CD34 + cells in maternal blood could be validated as a potential marker to predict the development of possible kidney malformations.