Effect of mandarin peel extract on experimentally induced arthritis in male rats. (4th March 2021)

• Record Type: Journal Article
• Authors: Sakr, Hader I.; Khowailed, Akef A.; Gaber, Safy S.; Ahmed, Osama M.; Eesa, Ahmed N.
• Is Part Of: Archives of physiology and biochemistry. Volume 127:Number 2(2021)
• Page Start: 136
• Page End: 147
• Publication Date: 2021-03-04
• Subjects: Rheumatoid arthritis -- pro-inflammatory mediators -- mandarin peel extract -- oxidative stress; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2019.1623263
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Background: Rheumatoid arthritis (RA) is associated with joint damage. For treatment, non-steroidal anti-inflammatory drugs (NSAIDs), steroidal agents, and immune-suppressants are used. Their side-effects require a safe and effective natural alternative. Animals and methods: Thirty-six male albino rats, half kept under observation for 1 week (group I) and others for 2 weeks (group II) were used. Each group was subdivided into: normal (A), RA (B), and oral mandarin-peel extract (MPE) treated (C). Ankle diameter, serum levels of RF, interleukin (IL)-1β, TNFα, IL-4, IL-10, liver homogenates malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and nitric oxide (NO) were measured together with the histopathological examination. Results: MPE treatment was associated with increased serum IL-4, IL-10, liver homogenates GSH, and SOD, and decreased ankle diameter, serum RF, IL-1β, TNFα, liver homogenates MDA, NO, inflammatory cell infiltrate, and necrosis. Two weeks' treatment was better. Conclusions: MPE has useful effects in alleviating the disturbed ankle diameter, serum pro- and anti-inflammatory mediators, oxidative stress, and ankle joint histopathology in rheumatic rats.