Maternal and fetal thiol/disulfide homeostasis in fetal growth restriction. (19th May 2021)

• Record Type: Journal Article
• Authors: Eroglu, Hasan; Turgal, Mert; Senat, Almila; Karakoc, Gokhan; Neselioglu, Salim; Yucel, Aykan
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 34:Number 10(2021)
• Page Start: 1658
• Page End: 1665
• Publication Date: 2021-05-19
• Subjects: Intrauterine growth restriction -- oxidative stress -- perinatal complications -- thiol/disulfide balance -- hypoxia; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2019.1646239
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Purpose: To evaluate thiol/disulfide homeostasis in both maternal and fetal compartment in the presence of fetal growth restriction (FGR). Materials and methods: A prospective case-control study was carried out in women with FGR ( n : 40) or normally growing fetus ( n : 40). FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Maternal serum and fetal cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance. Results: Native thiol, total thiol and disulfide amounts were decreased in the maternal serum and fetal cord blood of babies born to women with FGR ( p < .05). The most sensitive marker was maternal native thiol (82.5, 95% confidence interval, 67.22–92.66%), while the maternal total thiol had highest specificity value (77.5, 95% confidence interval, 61.55–89.16%). Conclusions: Maternal and fetal serum thiol/disulfide profiles may use prediction of FGR severity and its neonatal outcome.