The role of mTOR signalling pathway in hypoxia-induced cognitive impairment. (4th May 2021)

• Record Type: Journal Article
• Authors: Abdo Qaid, Entesar Yaseen; Zulkipli, Ninie Nadia; Zakaria, Rahimah; Ahmad, Asma Hayati; Othman, Zahiruddin; Muthuraju, Sangu; Sasongko, Teguh Haryo
• Is Part Of: International journal of neuroscience. Volume 131:Number 5(2021)
• Page Start: 482
• Page End: 488
• Publication Date: 2021-05-04
• Subjects: Hypoxia -- mTORC1 -- mTORC2 -- HIF-1 -- BDNF -- cognitive impairment; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2020.1746308
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract: Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.